MATH2307 Bioinformatics and Biological Modelling
Later Year Course
| Offered By | Department of Mathematics |
|---|---|
| Academic Career | Undergraduate |
| Course Subject | Mathematics |
| Offered in | Second Semester, 2009 and Second Semester, 2010 |
| Unit Value | 6 units |
| Course Description |
The course begins with a detailed discussion of sequence alignment algorithms that are critical for assessing the relatedness of DNA, RNA and amino acid sequences. We then proceed to studying Markov chains and hidden Markov models as important examples of biological models for such sequences. The main algorithms and several applications will be explained. Next, various approaches to protein folding are discussed. Finally, evolutionary models and several methods of phylogenetic reconstruction are explained. The course is accompanied by computer lab sessions where we explore major biological databases, sequence similarity search and phylogenetic tools. |
| Learning Outcomes |
On satisfying the requirements of this course, students will have the knowledge and skills to: 1. Understand basic models for the evolution of biological sequences and protein folding.2. Understand and apply the essential methods for phylogenetic reconstruction. 3. Apply phylogenetic reconstruction software to the main databases of biological sequences. 4. Understand and apply basic probabilistic concepts such as probability spaces, conditional probability, Markov chains, and stationary distributions. |
| Indicative Assessment |
Assessment will be based on:
|
| Workload |
36 lectures and ten tutorials |
| Areas of Interest | Mathematics |
| Requisite Statement |
12 units of Group A courses in Mathematics, including MATH1014 or MATH1116. |
| Science Group | B |
The information published on the Study at ANU 2009 website applies to the 2009 academic year only. All information provided on this website replaces the information contained in the Study at ANU 2008 website.
