Intelligent use of molecular data requires an understanding of DNA both as a biomolecule and as an information source. This course is designed to provide a from-the-ground-up coverage of key topics in molecular evolution. The emphasis is on understanding how DNA records information that reveals evolutionary and ecological patterns and processes. Each topic covered includes both theoretical and practical aspects of bioinformatics, illustrated with recent case studies in contemporary research.We will include current techniques, with hands-on experience of latest software. This course covers:

• Basic DNA structure in order to understand DNA extraction techniques
• DNA replication in order to understand PCR
• Genetic divergence to highlight species identification through DNA barcoding
• Mutation and substitution to provide a understanding of alignment
• Selection and drift to provide the basis for inferring phylogeny.

To extend and develop these bioinformatic skills, students should also undertake BIOL8242.

On satisfying the requirements of this course, students will have the knowledge and skills to:

1. understand the importance of DNA both as a biomolecule and as an information source.
2. use computer-based tools such as Genbank in searching, sequence alignment and phylogenetic analysis.
3. evaluate and analyse results in the context of molecular evolution with emphasis on understanding how DNA records information that reveals evolutionary and ecological patterns and processes.

Assessment will be based on:

• Computer-based tutorials (60%; LO 1-3)
  
• Written reports (40%; LO1-3)
  

Completion of BIOL6004 and BIOL6006