This course covers the principles of the transmission and expression of genetic information, in both prokaryotes and eukaryotes. 

Topics to be covered include: 

• Cell structure and function
• DNA structure and packaging
• DNA replication and repair
• Transcription
• Regulation of gene expression
• RNA processing
• Protein synthesis
• The genetic code
• Protein trafficking and degradation

Note: Graduate students attend joint classes with undergraduates but are assessed separately.

On satisfying the requirements of this course, students will have the knowledge and skills to:

1.Explain the basic processes involved in the expression of genetic information (DNA replication; mutagenesis and DNA repair; mRNA transcription and processing; gene regulation; protein synthesis and trafficking;  the cell cycle)
2. Understand the roles and functions of these processes
3. Predict outcomes when these processes are perturbed by mutation (genetic disease) or the use of inhibitors and drugs
4. Understand differences between gene organization in prokaryotes and eukaryotes
5. Interpret and analyse experimental and theoretical problems involving these processes
6. Apply knowledge and research applications for example, in designing experiments or analysing examples from the literature

Assessment will be based on:

• Laboratory reports to apply knowledge to experimental/theoretical problem (30%; LO 1,3,4, 5)
• Tutorial tests to demonstrate mastery and understanding of content  (20%; LO 1, 2, 3, 4)
• Assignments - linked to the laboratory course to extend understanding and application of both theory and techniques learnt (20%; LO 3, 5, 6)
• Final exam to demonstrate understanding, interpretation and problem solving (30%; LO 1, 2, 3, 4, 5)

Two lectures per week; five laboratory sessions of up to four hours each; ten one-hour tutorials.

Bachelor degree; with first year Biology and first year Chemistry.

Requires Bachelor of Science or equivalent with a major in the field of biological sciences with relevant experience or academic achievement; specific knowledge in the area of cell and molecular biology is required.