This course covers the principles of molecular genetics, introducing the molecular mechanisms involved in the storage and expression of genetic information in both prokaryotes and eukaryotes. Topics to be covered include: cell structure and function; genome structure and evolution, DNA structure and packaging; DNA replication and repair; transcription; regulation of gene expression; RNA processing; protein synthesis and the genetic code; protein trafficking.   These processes will be illustrated with case studies, focussing especially on the human genome and genetic disease.

Honours pathway option (HPO)

The honours pathway option is open to all students and involves participation in PeerWise, a web-based activity where students create, answer, rate and discuss multiple choice questions based on the course content.  To qualify for the HPO, a minimum number of questions and comments must be posted.

On satisfying the requirements of this course, students will have the knowledge and skills to:

1. Explain the basic processes involved in the expression of genetic information (DNA replication; mutagenesis and DNA repair; mRNA transcription and processing; gene regulation; protein synthesis and trafficking;  the cell cycle)
2. Understand the roles and functions of these processes
3. Predict outcomes when these processes are perturbed by mutation (genetic disease) or the use of inhibitors and drugs
4. Understand differences between gene organization in prokaryotes and eukaryotes
5. Interpret and analyse experimental and theoretical problems involving these processes

Assessment will be based on:

• Laboratory reports to apply knowledge to experimental/theoretical problem (30%; LO 1, 3, 4, 5)
• Tutorial tests to demonstrate mastery and understanding of content  (20%; LO 1, 2, 3, 4)
• Final exam to demonstrate understanding, interpretation and problem solving (50%; LO 1, 2, 3, 4, 5)

Two lectures per week; five laboratory sessions of up to four hours each; ten one-hour tutorials.

BIOL1003 and BIOL1004 and CHEM1101 (or CHEM1014/16)

Genetics: a conceptual approach. (2012) Pierce, B. 4th edition